Manic Minds: Mania's Mad History and Its Neuro-FutureFrom its first depictions in ancient medical literature to contemporary depictions in brain imaging, mania has been largely associated with its Greek roots, "to rage." Prior to the nineteenth century, "mania" was used interchangeably with "madness." Although its meanings shifted over time, the word remained layered with the type of madness first century writers described: rage, fury, frenzy. Even now, the mental illness we know as bipolar disorder