L-5-MTHF SAPScience based metabolically active folic acid. Size Format: 60 Capsules Folic acid, or folate, is a B vitamin that must be derived from either dietary sources or via supplementation. Folate is necessary for a biochemical process in the body called "methylation" or "one carbon metabolism." This process does not work adequately in a significant number of individuals who have a genetic polymorphism, and it may contribute to a host of different concerns,